Altered Physiology the case study analysis scenario A 42-year-old man comes to clinic with chief complaint of pain, redness, and swelling of his right calf. He states that he had been working in his yard using a string trimmer when the trimmer slipped and cut his leg. He cleaned the wound with water from the garden hose and covered the wound with a large Band-Aid. Several days later, he developed fever to 100.6˚ F and chills and noticed that his leg was swollen and red. He comes to the emergency department for definitive care. Develop a 2-page case study analysis in which you: · Explain why you think the patient presented the symptoms described. · Identify the genes that may be associated with the development of the disease. · Explain the process of immunosuppression and the effect it has on body systems. Include a title page, introduction, summary, and references. In developing your discussion posts, I will encourage you to think about cellular pathophysiology. I always want to know what is happening in the cells that produce the clinical manifestations of the disease. Your post will be stronger if you do not cite patient educational sites such as WebMD, Mayo clinic Healthline etc. To this end, Wikipedia is never acceptable as an academic source. You will see point deductions if you cite these sources in your posts and paper. Required Reading McCance, K. L. & Huether, S. E. (2019). (8th ed.). St. Louis, MO: Mosby/Elsevier. ·  Chapter 1: Cellular Biology; Summary Review ·  Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents(pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review · Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases, · Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review · Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review · Chapter 7: Innate Immunity: Inflammation and Wound Healing · Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review · Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review · Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review · Chapter 11: Stress and Disease (stop at Stress, illness & coping) Summary Review · Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review · Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review

Title: Altered Physiology: A Case Study Analysis of a Patient with Symptoms of Pain, Redness, and Swelling of the Calf

This case study analysis delves into the presenting symptoms of a 42-year-old man who presents with pain, redness, and swelling in his right calf. The patient reports an incident where he accidentally cut his leg with a string trimmer while working in his yard. Despite cleaning the wound and applying a Band-Aid, he developed fever, chills, and noticed the worsening of symptoms, prompting him to seek definitive care at the emergency department. This analysis aims to explain the reasons behind the patient’s symptoms, identify possible genes associated with the disease’s development, and explore the process of immunosuppression and its effects on the body systems.

Explanation of Symptoms Presentation:
The patient’s symptoms of pain, redness, and swelling of the calf can be attributed to an infectious process known as cellulitis. Cellulitis is a bacterial infection that affects the skin and the underlying tissues. This condition commonly occurs when bacteria enter the body through a break in the skin and multiply, triggering an inflammatory response. In the case of this patient, the cut on his leg served as the portal of entry for bacteria, leading to the development of cellulitis.

The inflammatory response in cellulitis involves the release of pro-inflammatory mediators like cytokines and chemokines, leading to vasodilation, increased vascular permeability, and the recruitment of immune cells to the site of infection. This cascade of events results in the characteristic clinical manifestations such as redness, swelling, and pain. The patient’s fever and chills could be indicative of a systemic response to the infection.

Identification of Associated Genes:
Multiple genes may be associated with the development of cellulitis, including those involved in the immune response, regulation of inflammation, and skin barrier function. Genetic variants in genes encoding for immune receptors, such as toll-like receptors (TLRs) and pattern recognition receptors (PRRs), may influence susceptibility to bacterial infections. These receptors are involved in the recognition of microbial components, triggering the innate immune response.

Additionally, genetic polymorphisms in genes encoding for cytokines, chemokines, and their receptors can affect the intensity and duration of the inflammatory response. Variants in genes involved in skin barrier function, such as those encoding for proteins like filaggrin, may compromise the integrity of the skin, making individuals more susceptible to developing skin infections like cellulitis. Further investigation and genetic testing would be necessary to identify specific genes that may be associated with the development of cellulitis in this particular case.

Understanding the Process of Immunosuppression:
Immunosuppression refers to the suppression or weakening of the immune system, leading to a decreased ability to mount an effective immune response against pathogens. This can occur as a result of various factors, including medical conditions, medications, and environmental exposures.

In the context of this case, the patient may have experienced immunosuppression due to the initial cut and subsequent bacterial infection. The trauma caused by the cut itself can impair the local immune response, compromising the ability to effectively clear invading pathogens. Additionally, the use of non-sterile water from the garden hose to clean the wound introduces potential contaminants, further exacerbating the risk of infection.

The effect of immunosuppression on body systems is vast. It can result in impaired immune cell function, decreased production of antibodies, and reduced activation of immune signaling pathways. Consequently, the body becomes more susceptible to infections, and the ability to effectively eliminate pathogens is compromised.

In conclusion, the presenting symptoms of pain, redness, and swelling of the patient’s calf can be attributed to cellulitis, an infectious process that occurred as a result of a cut with a string trimmer. The development of cellulitis may involve genetic factors associated with immune response, regulation of inflammation, and skin barrier function. Furthermore, the process of immunosuppression can weaken the body’s ability to mount an effective immune response against pathogens, further exacerbating the infection. Understanding the cellular pathophysiology of these processes provides valuable insights into the disease development and manifestation, facilitating appropriate diagnosis and treatment strategies for the patient.