Anne Kolsky    1 posts   Re: Topic 8 DQ 2  Clinical Significance and Statistical Significance  Clinical significance can help to validate whether a treatment effect has practical importance and if it has a real effect on daily life. If a treatment makes a noticeable difference and improvement to a patient, then this is considered clinically important and significant.  Statistical significance is measured through confidence intervals and p-values that quantify the significance of a treatment or trial’s effect on a patient or sample. For instance, if the p value is less than 0.05, then it tells us the trial is statistically significant. This means the result did not happen by chance. However, it does not tell us the importance or meaningfulness of the findings, only that there is something “real” happening (Leyva De Los Rios, 2017).  How Clinical Significance Can Support Positive Outcomes in Capstone Project  Clinical Significance can greatly support the project in many ways. For the PICOT, if scores that are compared indicate kindergarten readiness by virtue of screening over not screening, then statistical significance is established. If a body of students show marked improvements in grades, attendance, attitude, graduation rates, and staying clean, sober, and out of criminal trouble, it will lead to huge bragging rights for many stakeholders as evidenced by statistical significance in longitudinal studies that would also be established (Page, 2014).   Leyva De Los Rios, C. (2017, March 23). Retrieved from  Page P. (2014). Beyond statistical significance: clinical interpretation of rehabilitation research literature.   International journal of sports physical   therapy, 9(5), 726–736.Retreived from

Clinical significance and statistical significance are two important concepts in research that help validate the importance and relevance of findings. While statistical significance measures the likelihood of obtaining a result by chance, clinical significance focuses on whether a treatment or intervention has practical importance and real-world impact on individuals’ lives. In this response, we will explore the concepts of clinical significance and statistical significance and discuss how clinical significance can support positive outcomes in a capstone project.

Statistical significance is typically measured using confidence intervals and p-values. A p-value less than 0.05 is commonly used as a threshold to determine statistical significance. If the p-value is below this threshold, it suggests that the result is unlikely to have occurred by chance alone, and there is genuine effect or difference present. However, statistical significance does not indicate the magnitude or meaningfulness of the effect. It only tells us that there is a significant finding in the data.

On the other hand, clinical significance looks beyond statistical values and focuses on the practical importance of an intervention. It considers whether the observed effect or difference is meaningful and has a substantial impact on individuals’ lives. Clinical significance is often assessed through various measures, such as effect sizes, clinical judgments, and patient-reported outcomes. For example, in a clinical trial testing a new treatment for depression, clinical significance would involve assessing whether the treatment not only improves patients’ symptoms but also enhances their overall well-being and functioning in daily life.

In the context of a capstone project, clinical significance can play a crucial role in supporting positive outcomes. Suppose the project aims to investigate the effectiveness of a screening tool in identifying kindergarten readiness. If the scores obtained from the screening tool are significantly higher compared to not screening, it establishes statistical significance. However, clinical significance would involve determining whether these higher scores actually translate into improved outcomes for the children, such as better grades, attendance, attitudes, graduation rates, and reduced involvement in criminal activities. Clinical significance would examine whether the use of the screening tool leads to tangible improvements in the lives of the children and supports positive educational and developmental outcomes.

In a capstone project, demonstrating clinical significance is important as it provides evidence that the proposed intervention or approach has real-world impact and can bring about positive changes. It allows stakeholders, such as educators, policymakers, and parents, to see the practical benefits of the project and increases their confidence in its effectiveness. Additionally, clinical significance helps in the dissemination of the project findings to a wider audience, as it demonstrates the relevance and applicability of the research results in various settings.

In conclusion, clinical significance and statistical significance are both essential aspects of research. While statistical significance assesses the likelihood of obtaining results by chance, clinical significance evaluates the practical importance and impact of findings on individuals’ lives. In a capstone project, demonstrating clinical significance is crucial for supporting positive outcomes and showcasing the practical benefits and relevance of the proposed intervention. By considering the real-world impact of the project, clinical significance enhances stakeholders’ confidence in the effectiveness of the intervention and facilitates the dissemination of the project findings to a wider audience.