DNP-820A: Translational Research and Evidence-Based Practice.


DNP-820A: Translational Research and Evidence-Based Practice course concentrate on a core set of skills and knowledge application activities linked to the translation of research into practice, the evaluation of practice, and improvement of health care outcomes. DNP-820A: Translational Research and Evidence-Based Practice, learners examine evidence to guide improvements in practice and outcomes of care. Literature reviews focus on gaps or tensions in the translation of research into practice while ethical considerations are also examined in the context of health care research. Students are expected to integrate and synthesize core program competencies and specialty practice requirements necessary to demonstrate proficiency in advanced nursing practice.


What is translational research?

Translational research is the process of applying knowledge from basic biology and clinical trials to methods and tools that address critical medical needs. It uses an integrated team of professionals who are focused on translating useful information from laboratories to doctors’ offices and hospitals. In short, it is specifically created to improved health outcomes in health care facilities by producing more meaningful, applicable results that directly benefit human health.

Importance of translational research in health care.

Translational research has various benefits in health care. Some of these benefits include:

  • It encourages and promotes multidisciplinary collaboration among laboratory and clinical researchers.
  • Translational research incorporates the desires of the general public, with communities being engaged to determine their needs for health innovation and,
  • It identifies and supports the adoption of best medical and health practices

Stages of translational research.

T0 (Basic science research).

This stage involves preclinical and animal studies. That is, the defining mechanisms, targets, and lead molecules.

T1 (Translation to humans).

This stage of translational research involves the proof of concept (phase 1 clinical trials). In this stage, new methods of diagnosis, treatment, and prevention are discussed.

T2 (Translation to patients).

This is the phases 2 and 3 of clinical trials. This stage comprises controlled studies leading to effective care.

T3 (Translation to practice).

This is the phase 4 clinical trials and clinical outcomes of the research. It involves the delivery of recommended and timely care to the right patient.

T4 (Translation to the community).

This stage comprises population-level outcomes research. It involves assessing and determining the true benefit of the research to society.


Summary of stages of translational research.

  • The first three stages of translational research, that is, T0, T1, and T2, involve the translation of basic science to human studies.
  • The last stages of translational research involve the translation of new data into the clinic and health decision-making.

What is evidence-based practice?

Evidence-based practice (EBP) in nursing is a combination of research evidence, clinical expertise,DNP-820A: Translational Research and a patient’s preferences. This problem-solving approach to clinical practice encourages nurses to provide individualized patient care.

Five steps of evidence-based practice in nursing.

  1. Form a clinical question to identify a problem.
  2. Gather the best evidence.
  3. Analyze the evidence.
  4. Apply the evidence to clinical practice.
  5. Assess the result.

Difference between research and evidence-based practice.

Research is used to generate new knowledge or validate existing knowledge based on theory. On the other hand, evidence-based practice is used the best available evidence to make informed patient-care decisions.


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