Therapeutic Drug Monitoring

Therapeutic Drug Monitoring

 

Therapeutic Drug Monitoring

 

Therapeutic Drug Monitoring Definition:

Therapeutic drug monitoring (TDM) is testing that measures the amount of certain medicines in your blood. It is done to make sure the amount of medicine you are taking is both safe and effective.
Therapeutic Drug Monitoring

Answer: Therapeutic Drug Monitoring

Drug absorption, distribution in the body, action, metabolism, and excretion can all alter with age. The elderly are more prone to encounter adverse effects as well as trouble taking their prescription.

Despite an age-related decrease in small-bowel surface area, delayed gastric emptying, and an elevation in stomach pH, changes in medication absorption for most medicines are clinically insignificant.

With the increased usage of potassium-raising medicines, the number of people at risk of developing life-threatening hyperkalaemia is projected to rise.

We recommend that patients with impaired renal potassium excretion due to renal disease, particularly those taking angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, potassium-sparing diuretics, or nonsteroidal anti-inflammatory drugs, be warned about the risk of hyperkalaemia by their doctors and dieticians. Prescribers of these medications should enquire about their patients’ usage of potassium-containing salt substitutes. Clearer cautions should also be included in the package information for potassium-containing salt replacements. (NCB JOURNAL)

Question: Therapeutic Drug Monitoring

  1. Therapeutic drug monitoring is a frequent practice in health care. How does age affect drug absorption, metabolization and excretion?
  2. The use of salt substitutes can cause hyperkalemia in older adults when use in conjunction with what types of drugs?
  3. Describe how you would prevent and evaluate risk factors for medication nonadherence in older adults?

References.

NCB JOURNAL on Danger of salt substitutes that contain potassium in patients with renal failure – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1124926/

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